Intervention effect of injury control orthopedic strategy on fat embolism syndrome associated with long shaft fracture of lower limb / 中国骨伤

OBJECTIVE@#To observe the intervention effect of damage control orthopaedic(DCO) strategy on fat embolism syndrome(FES) associated with long shaft fracture of lower limbs.@*METHODS@#Retrospective analysis was made on the clinical data of 163 patients with FES associated with lower limb long shaft fractures admitted from January 2015 to May 2021. They were divided into two groups based on the time point of implementing DCO strategy in January 2018. Total of 92 patients were admitted from January 2015 to December 2017 as the control group, and other 71 patients were admitted from January 2018 to May 2021 as the intervention group. The hospital mortality, arterial oxygen saturation (SaO2), arterial partial pressure of oxygen (PaO2) and oxygenation index (OI), hemoglobin (Hb), platelet count(PLT), Harris score of hip joint, HSS score of knee joint, AOFAS score of ankle joint, clinical efficacy and complications were observed and compared between two groups.@*RESULTS@#Total of 163 patients were followed up for 12 to 18 months with an average of (16.91±1.22) months. The in-hospital mortality rate in the intervention group was 2.82% (2/71), and that in the control group was 16.30% (15/92), the difference between two groups was statistically significant(χ2=6.455, P<0.05). After the intervention, SaO2, PaO2 and OI in two groups were higher than those before the intervention(P<0.05), and after the intervention, SaO2, PaO2 and OI in two groups were statistically significant(P<0.05). Hb and PLT in two groups after intervention were higher than those before intervention (P<0.001), and there was statistically significant difference in Hb and PLT between two groups after intervention (P<0.05). The Harris score of hip joint, HSS score of knee joint and AOFAS score of ankle joint in both groups after 3 months of treatment were better than those before treatment (P<0.05). The total clinical effective rate of the intervention group was higher than that of the control group(χ2=4.194, P<0.05). The total incidence of complications in the intervention group was lower than that in the control group(χ2=4.747, P<0.05).@*CONCLUSION@#DCO strategy is helpful to reduce the in-hospital mortality of patients with FES associated with long shaft fracture of lower extremities, eliminate FES symptoms and stabilize vital signs, gain time advantage for phase Ⅱ definitive surgery, and has significant clinical intervention effect, which is worth popularizing.

Metacarpal fractures treatment: comparasion between kirschner wire and intramedullary screw / Tratamento de fraturas metacarpais: comparação entre fios de kirschner e fixação intramedular

ABSTRACT Introduction: Metacarpal fractures are common and can be treated surgically using Kirschner wires (K-wires) or intramedullary fixation with compression screws (IMCS). Objectives: Analyze the postsurgical results from treating the metacarpal extra-articular fractures through the retrograde Kirschner wire technique, and compare it with the intramedullary compression screw fixation. Methods: Retrospective and quantitative studies were to analyze patients' medical records, and a postsurgical evaluation questionnaire was given to the patients, who were divided into K-wire and IMCS. Results: The period of immobilization with a splint took six weeks for the K-wire group and four weeks for the IMCS group. The average time for consolidation took, respectively, fifty-seven days and forty-seven days. The first group could restart their activities twenty-two days after the other, and the average force value of the treated hand, when compared with its contralateral, was 93.9% and 95.4%, respectively. Between the operated hand and its contralateral, there was a difference of 16° in the total measures of the metacarpophalangeal and interphalangeal joint's range of movement among the K-wire group and 5° among the IMCS group. Conclusion: The patients who participated in this study showed excellent results after surgery, and both treatments were proven to be safe and reliable. Evidence level III; Retrospective comparative study .

RESUMO Introdução: Fraturas dos metacarpos são frequentes e podem ser tratadas de forma cirúrgica com os fios de Kirschner (FK) e Fixação Intramedular com Parafuso de Compressão (FIPC). Objetivo: Analisar os resultados pós-operatórios do tratamento das fraturas extra-articulares dos metacarpos pela técnica retrógrada com fios de Kirschner e comparar com a fixação intramedular utilizando parafuso de compressão. Métodos: Estudo retrospectivo, quantitativo, com análise de prontuários, utilizando questionários de avaliação pós-operatória em dez pacientes divididos em dois grupos: FIPC e FK. Resultados: O período de imobilização com tala nos grupos FK e FIPC foram de seis e quatro semanas respectivamente, já o tempo médio para consolidação foi de 57 e 47 dias respectivamente. O grupo FK retornou as atividades laborais após os FIPC. O valor médio de força na mão acometida comparada a contralateral foi de 93,9% no grupo FK, e no FIPC de 95,4%. Medidas da soma de amplitude de movimento das articulações metacarpofalangeanas e interfalangeanas no grupo FK obtiveram diferença média entre as mãos operada e a contralateral de 16°, já na FIPC observou-se 5°. Conclusão: Os pacientes estudados apresentaram excelentes resultados pós-operatórios e ambos os tratamentos provam ser seguros e confiáveis. Nível de evidência III; Estudo retrospectivo comparativo .

Research progress of predictive potential of the body mass index in fracture risk of children / 中华实用儿科临床杂志

The increasing prevalence of obesity in children worldwide has been a global healthy issue.It is important to identify the effect of fat mass on the bone, which contributes to promote the peak bone mass and prevent osteo-porosis-induced fracture.Body mass index (BMI), as an index to evaluate the state of obesity, is simple and easy to measure, and is suitable for self-test of a large range of people.This review aims to discuss the role of BMI in evaluating the interaction between obesity and bone density, and the predictive potential in fracture risk of children.

Fatores de risco para osteoporose em uma amostra da população de atenção primária em São Paulo, Brasil / Risk factors for osteoporosis in a sample of the primary attention population in São Paulo, Brazil

Objetivo: esse estudo teve como objetivo avaliar a instrução sobre osteoporose de uma amostra da população que frequenta o Centro de Saúde Butantã (CSE), visando incentivar a forma mais adequada de prevenção e/ou tratamento. Metodologia: Foi elaborado e aplicado, durante um mês, um questionário para identificar os fatores de risco de 101 pacientes, de ambos os sexos. Resultados: do total desses pacientes, 49% tinham idade inferior a 45 anos, 33% entre 45 e 65 anos e 18% acima de 65 anos. A cor branca prevaleceu em 66%, sendo que 36% do total possuíam hipertensão, 10% diabetes e 7% outras doenças crônicas. Em relação ao índice de massa corpórea (IMC), 4% estavam abaixo de 20Kg/m2, 37% eutróficos, 30% com sobrepeso, 24% com obesidade grau I e 5% com IMC superior a 35Kg/m2. Foi verificado que 76% da população era sedentária, 35% fumantes, 32% com consumo alcoólico inferior a 3 vezes na semana, 3% superior a 3 vezes e 65% sem consumo de álcool. Quanto a ingestão de leite, 37% não o consumiam e 40% apenas 1 vez ao dia. Não houve diferença estatística entre as pessoas que conheciam ou não a osteoporose, sendo que 60% tinham conhecimento sobre a doença, porém esse grau de instrução não implicou em diferenças nos hábitos de vida. Discussão: em 100% da amostra estudada foi encontrado pelo menos 1 fator de risco para o seu desenvolvimento, principalmente a baixa ingestão de cálcio e a falta de atividade física, confirmando a importância da intervenção nesses fatores preveníveis.

Objective: this study aimed to evaluate the education on osteoporosis in a sample of the population who attends the Center for Health Butantã (CSE), to encourage the most appropriate way of preventing and / or treatment. Methodology: was developed and implemented over a month, a questionnaire to identify risk factors of 101 patients of both sexes. Results: of the total of these patients, 49% were below 45 years, 33% between 45 and 65 and 18% over 65 years. The white prevailed in 66% and 36% of the total had hypertension, diabetes 10% and 7% other chronic diseases. In relation to body mass index (BMI), 4% were below 20Kg/ m2, 37% normal, 30% overweight, 24% with obesity grade I and 5% with BMI greater than 35kg/m2. It was found that 76% of the population was sedentary, 35% smokers, 32% with alcohol consumption less than 3 times a week, 3% more than 3 times and 65% with no consumption of alcohol. As the intake of milk, not the 37% and 40% consumed only 1 day. There was no statistical difference between people who knew or not osteoporosis, while 60% had knowledge about the disease, but this level of education did not lead to differences in living habits. Discussion: in 100% of the studied sample was found at least 1 risk factor for its development, especially the low calcium intake and lack of physical activity, confirming the importance of intervention in those preventable factors.

Reparo inicial de defeito ósseo crítico na calvária de rato após aplicação de ondas vibratórias / Initial repair of critical bone defect in rat calvary after the application of vibratory waves

Introdução: fraturas ósseas extensas representam grande causa de morbidade e geram custos para o serviço de saúde. A vibração de baixa magnitude e alta frequência foi proposta como um tratamento alternativo para aumentar a massa óssea. Objetivo: Avaliar histomorfologicamente o reparo inicial de defeitos ósseos críticos após aplicação de ondas mecânicas vibratórias Metodologia: foram utilizados 10 Rattus norvegicus. Confeccionou-se defeitos críticos de 8,5 mm de diâmetro na calvária dos ratos. Os animais foram distribuídos em dois grupos: Grupo Controle de Defeito Ósseo (GCDO) e Grupo Experimental de Vibração Imediata (GEVI). Animais do GEVI foram submetidos a ondas vibratórias de 60 Hz e aceleração vertical de 0,3 g; elas foram aplicadas três vezes/ semana, durante vinte minutos. Após quinze dias do ato operatório, os animais foram eutanasiados para a mensuração da extensão do defeito. Considerando que estes defeitos tinham o mesmo diâmetro inicial, admitiu-se como indicador indireto de deposição osteóide, a redução da extensão linear final dos mesmos. Resultados: observou-se neoformação de matriz osteoide, restrita às bordas ósseas, em ambos os grupos. A média de extensão linear, em milímetros, do defeito ósseo do GEVI foi de 5,83 (DP=0,79) e no GCDO, foi de 6,62 (DP= 0,63). Não houve diferença estatisticamente significante entre as médias (U=8,00, z=-1,604, p=0,132). Conclusão: evidenciou-se resposta osteogênica a partir da utilização da terapêutica vibratória, contudo de forma estatisticamente não-significante. Deste modo, o presente estudo demonstrou que a utilização das ondas vibratórias não favoreceu um reparo ósseo estatisticamente significante, no período e regime vibratório estudados.

Introduction: extensive bone fractures represent a major cause of morbidity and generate costs for the health service. Vibration of low magnitude and high frequency has been proposed as an alternative treatment to increase bone mass. Objective: to evaluate histomorphologically the initial repair of critical bone defects after application of vibrating mechanical waves. Methodology: 10 Rattus norvegicus were used. Critical defects of 8.5 mm in diameter were made in the calvaria of the rats. The animals were divided into two groups: Bone Defect Control Group (GCDO) and Experimental Immediate Vibration Group (GEVI). GEVI animals were submitted to 60 Hz vibrating waves and 0.3 g vertical acceleration; they were applied three times/week, for twenty minutes. Fifteen days after the surgery, the animals were euthanized to measure the extent of the defect. Considering that these defects had the same initial diameter, a reduction in their final linear extension was admitted as an indirect indicator of osteoid deposition. Results: neoformation of an osteoid matrix, restricted to bone borders, was observed in both groups. The mean linear extension, in millimeters, of the GEVI bone defect was 5.83 (SD = 0.79) and in the GCDO, it was 6.62 (SD = 0.63). There was no statistically significant difference between the means (U = 8.00, z = -1.604, p = 0.132). Conclusion: an osteogenic response was evidenced from the use of vibratory therapy, however in a statistically non-significant way. Thus, the present study demonstrated that the use of vibrating waves did not favor a statistically significant bone repair, during the studied period and vibration regime

Perfil das fraturas faciais em um serviço de emergência no Maranhão / Profile of facial fractures in an emergency service in Maranhão

O bjetivo: Avaliar o perfil das fraturas faciais em pacientes atendidos em serviço de emergência no estado do Maranhão. Método: Utilizou-se abordagem indutiva, com procedimento estatístico-descritivo e técnica de documentação direta, cuja amostra foi selecionada por conveniência e constituída pelos pacientes internados em decorrência de trauma facial (n = 100). Os dados foram coletados a partir dos prontuários dos pacientes que consentiram a participação na pesquisa mediante assinatura do TCLE. A análise dos dados empregada foi descritiva e inferencial (qui-quadrado; p<0,05), utilizando o software Statistical Package for Social Sciences. Resultados: O gênero masculino foi o mais acometido (63%), com a faixa etária de 19 a 30 anos (34%). Os atendimentos ocorreram frequentemente, no domingo (24%), e o acidente com motocicletas (56%) foi a principal etiologia. As principais fraturas identificadas foram na região mandibular (54%), maxilar (48%) e orbital (22%). O tratamento comumente realizado foi inclusão de miniplacas sem bloqueio intermaxilar (66%), com tempo de internação de 6-15 dias (49%). Conclusão: Houve maior prevalência de fraturas mandibulares em pessoas do gênero masculino com faixa etária jovem, sendo o acidente de motocicleta o principal fator etiológico e a ocorrência da maior parte dos casos nos finais de semana (domingo), com ingestão de bebida alcoólica... (AU)

Goal: Evaluate the profile of facial fractures in patients admitted in emergency care services in the state of Maranhão. Method: It was used na inductive approach, with a statistical-descriptive procedure and a right documentation technique, which sample was selected conveniently and constituted by the patients hospitalized because of facial trauma (n = 100). The data were collected through patients' medical reports who allowed their participating in the data research by signing the consent form. The data analysis applied was descriptive and inferential (qui-square; p<0,05), using the software Statistical Package for Social Sciences. Outcomes: the male gender was more affected (63%), with an age range from 19 to 30 years old (34%). The attendances occurred commonly on Sundays (24%) and the accident involving motorcycles (56%) was the major etiology. The main identified fractures were in the mandibular region (54%), jaw (48%) and orbital (22%). The treatment commonly performed was the application of miniplates withou intermaxillary blocking (66%), with admittance time between 6-15 days (49%). Conclusion: There was greater prevalence of mandibular fractures on male gender people in Young ages, being motorcycle accident the main etiological and the occurrence of most cases on the weekend (Sundays), involving alcoholic beverages ingestion... (AU)

Facial Paralysis in Longitudinal versus Oblique and Otic-Sparing versus Non Otic-Sparing Temporal Bone Fractures

OBJECTIVE: To compare the proportion of temporal bone fractures using traditional (longitudinal vs. transverse) and otic involvement (otic sparing vs. non-otic sparing) classification schemes and their relationship with the development of facial paralysis.METHODS:        Design:           Retrospective Case Series        Setting:         Tertiary Government Hospital       Participants:         Records of 49 patients diagnosed with temporal bone fracture in our institution from August 2016 to June 2018.RESULTS: A total of 41 records of patients with temporal bone fractures, 32 males, 9 females, aged 5 to 70 years-old (mean 37.5-years-old) were included.  In terms of laterality 23 (56%) involved the right and 17 (41%) the left side.  Traditionally classified, 32 (78%) were longitudinal and 9 (22%) were transverse. Using newer classification based on otic involvement and non-otic involvement, 38 (93%) were otic-sparing and 3 (7%) were non otic-sparing. Only 9 (22%) out of 41 total fracture patients developed facial paralysis, involving 7 of the 32 longitudinal fractures and 2 of the 9 transverse fractures, or 8 of the 38 otic-sparing and 1 out of 3 non otic-sparing fractures.CONCLUSION: Because of the small sample size, no conclusions regarding the proportion of temporal bone fractures using traditional (longitudinal vs. transverse) and otic involvement (otic sparing vs. non-otic sparing) classification schemes and their relationship with the development of facial paralysis can be drawn in this study.KEYWORDS: head injuries; head trauma; skull fracture; temporal bone fracture; motor vehicles; traffic accidents; facial paralysis

Facial paralysis in longitudinal versus oblique and otic-sparing versus non otic-sparing temporal bone fractures

Objective@#To compare the proportion of temporal bone fractures using traditional (longitudinal vs. transverse) and otic involvement (otic sparing vs. non-otic sparing) classification schemes and their relationship with the development of facial paralysis.@*Methods@#Design: Retrospective Case Series. Setting: Tertiary Government Hospital. Participants: Records of 49 patients diagnosed with temporal bone fracture in our institution from August 2016 to June 2018. @*Results@#A total of 41 records of patients with temporal bone fractures, 32 males, 9 females, aged 5 to 70 years-old (mean 37.5-years-old) were included. In terms of laterality 23 (56%) involved the right and 17 (41%) the left side. Traditionally classified, 32 (78%) were longitudinal and 9 (22%) were transverse. Using newer classification based on otic involvement and non-otic involvement, 38 (93%) were otic-sparing and 3 (7%) were non otic-sparing. Only 9 (22%) out of 41 total fracture patients developed facial paralysis, involving 7 of the 32 longitudinal fractures and 2 of the 9 transverse fractures, or 8 of the 38 otic-sparing and 1 out of 3 non otic-sparing fractures. @*Conclusion@#Because of the small sample size, no conclusions regarding the proportion of temporal bone fractures using traditional (longitudinal vs. transverse) and otic involvement (otic sparing vs. non-otic sparing) classification schemes and their relationship with the development of facial paralysis can be drawn in this study.

Delayed contralateral traumatic carotid cavernous fistula after craniomaxillofacial fractures

A carotid-cavernous sinus fistula is a rare condition in which an abnormal communication exists between the internal or external carotid artery and the cavernous sinus. It typically occurs within a few weeks after craniomaxillofacial trauma. In most cases, the carotid-cavernous sinus fistula occurs on the same side as the craniomaxillofacial fracture. We report a case of delayed carotidcavernous sinus fistula that developed symptoms 7 months after the craniomaxillofacial fracture. The fistula developed on the side opposite to that of the craniomaxillofacial fracture. Based on our experience with this case, we recommend a long follow-up period of 7–8 months after the occurrence of a craniomaxillofacial fracture. We also recommend that the follow-up should include consideration of the side contralateral to the injury.

Morbimortalidad en trauma ortopédico de alta energía: estudio descriptivo retrospectivo / Morbimortality of High-energy Orthopedic Trauma: a Descriptive Retrospective Study / Morbimortalidade em trauma ortopédico de alta energia: estudo descritivo retrospective

Resumen Objetivo: Describir la mortalidad y las principales complicaciones secundarias en los pacientes con trauma ortopédico de alta energía, admitidos en el servicio de urgencias del Hospital Universitario San Vicente Fundación. Metodología: Se llevó a cabo un estudio descriptivo retrospectivo de los pacientes, en un período de 18 meses, que cumplieron los criterios de inclusión luego de realizar la búsqueda en la base de datos del Hospital. Se revisaron 10 259 historias clínicas, de las cuales 161 cumplían los criterios de inclusión. Las variables cuantitativas se analizaron mediante medias y desviaciones estándar, y las cualitativas, a través de frecuencias y proporciones. El análisis estadístico se efectuó con el SPSS® 21. Resultados: La mayoría de pacientes afectados correspondía al sexo masculino (80,7 %), con edad promedio de 37,5 años; el principal hueso afectado fue la tibia (68,3 %). El principal mecanismo de trauma fue accidente de tránsito (82 %), siendo la motocicleta el vehículo involucrado con mayor frecuencia (65,8 %). La mortalidad fue baja, fallecieron tres pacientes. Las principales complicaciones fueron osteomielitis crónica y tromboembolismo pulmonar (7,4 y 6,8 %, respectivamente). Dieciséis pacientes requirieron ingreso a la unidad de cuidados intensivos (9,9 %), con un promedio de estancia de 6,9 días. Conclusiones: El trauma ortopédico de alta energía no es un factor de mortalidad independiente; sin embargo, impacta sobre la salud pública, debido a la discapacidad que esta lesión genera en individuos laboralmente activos, lo que lleva a ausentismo laboral y pérdida de la productividad.

Abstract Objective: to describe the mortality and the main secondary complications in patients with high-energy orthopedic trauma treated at the emergency service of the Hospital Universitario San Vicente Fundación. Methodology: descriptive retrospective study carried out in an 18-month period with patients following the inclusion criteria and after a search conducted in the hospital's database. 10,259 patient medical records were reviewed, out of which 161 followed the inclusion criteria. The quantitative variables were analyzed by standard means and deviations. The qualitative variables were analyzed by frequency and proportions. Results: most of the affected patients were males (80.7%), with a mean age of 37.5 years, the most affected bone was the tibia (68.3). Transit accident was the main mechanism of trauma (82%), and the most frequently involved vehicle was the motorcycle (65.8%). There was a low mortality of three patients. The main complications were chronic osteomyelitis and pulmonary thromboembolism (7.4% and 6.8%, respectively). Sixteen patients needed attention in the Intensive Care Unit (9.9%), remaining there for an average of 6.9 days. Conclusions: high-energy orthopedic trauma is not an independent mortality factor. However, it affects public health by generating medical leaves of active workers, which causes work absences and diminishes productivity.

Resumo Objetivo: Descrever a mortalidade e as principais complicações secundárias nos pacientes com trauma ortopédico de alta energia, tratados no serviço de urgências do Hospital Universitario San Vicente Fundación. Metodologia: foi feito um estudo descritivo retrospectivo dos pacientes, em 18 meses, respeitando critérios de inclusão após realizar a pesquisa na base de dados do Hospital. Revisaram-se 10 259 histórias clínicas, das quais 161 acatavam os critérios de inclusão. As variáveis quantitativas analisaram-se por meio de medições e desvios standards. As variáveis qualitativas analisaram-se através de frequências e proporções. Resultados: a maioria dos pacientes afetados eram de sexo masculino (80,7 %), com idade média de 37,5 anos, o principal osso afetado foi a tíbia (68,3 %). O principal mecanismo de trauma foi acidente de trânsito (82%), sendo a motocicleta o veículo envolvido com mais frequência (65,8 %). A mortalidade foi baixa, morreram três pacientes. As principais complicações foram a ostomielite crônica e o tromboembolismo pulmonar (7,4 e 6,8 %, respetivamente). Dezesseis pacientes precisaram atenção na Unidade de Terapia Intensiva (9,9%), com média de tempo na uti de 6,9 dias. Conclusões: o trauma ortopédico de alta energia não é um fator de mortalidade independente. Porém, afeta a saúde pública pelo impedimento gerado em pessoas que trabalham, porque elas devem se ausentar dos seus labores e a produtividade diminui.

Management of Post Traumatic Facial Nerve Palsy: A Hospital Based Study

Background: Facial nerve loss of motion by injury is normal cause after idiopathic. Facial paralysis accordingly of intra cranial, intra fleeting and additional transient limit harm or break and both. Sudden and prompt facial nerve paralysis require early surgical intervention for better result. Facial nerve decompression and termino- terminal anastomosis surgical intervention had done in present study. Methods: A prospective study of the 15 cases of traumatic facial nerve palsy attending Department of Otorhinolaryngology, Government Medical College, Shivpuri, MP. The complete clinic examination, otoscopic, audio logical, topo diagnostic, and radiological evaluation were done in all the patients. The outcome of these patients were done on the House-Brackmann nerve grading system. Results: All patients have infra nuclear type of facial nerve palsy. The maximum incidence of facial nerve paralysis found in the age group between 26 to 35 years. Out of 15 patients ,12 patients were normal hearing. Suprachordal (54%) involvement is the most common site of lesion in traumatic facial nerve paralysis. Conclusions: Sudden and immediate onset facial nerve paralysis need early surgical intervention for better outcome .facial nerve decompression were better outcome comparing to termino terminal anastmosis. The facial nerve paralysis prognosis depends upon degree of paralysis, duration of paralysis, site of injury and patients’ factors.

A case of life-threatening intraoperative diffuse alveolar hemorrhage during a femur fracture operation with suspected fat embolism: A case report

Diffuse alveolar hemorrhage (DAH) is a rare manifestation of trauma or long bone fracture. A relationship between fat embolism and DAH has been reported. A 73-year-old female developed sudden cardiac arrest during a femur fracture operation. Cardiopulmonary resuscitation (CPR) was repeated for about 130 minutes. During CPR, blood was detected in the endotracheal tube. Diffuse patch ground glass opacity appearance and increased pulmonary artery with bulging of interventricular septum toward the left ventricle were detected on a chest computed tomography scan. After full supportive care including ventilator therapy, the patient's condition became stabilized and she was extubated after 7 days. We report a case of DAH in the course of a suspected fat embolism during femur fracture operation. Although DAH is a rare manifestation of fat embolism, early diagnosis and aggressive treatment likely can decrease morbidity and mortality.

Reduction of Isolated Zygomatic Arch Fractures with Gillies Approach / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: The incidence of facial bone fracture is increasing. The zygomatic bone, due to its anatomical prominence, is the second most common site of all facial bone fractures. In this study, we present the clinical experiences of zygomatic arch fracture in a tertiary hospital and introduce the Gillies approach for reduction and its outcome results. SUBJECTS AND METHOD: We collected data from retrospective chart reviews of patients who underwent surgeries from 2010 to 2017 for zygomatic arch fractures at Chungbuk National University Hospital. Data were analyzed according to age, gender, cause of trauma, location of trauma, and clinical symptoms including trismus. All surgery was performed under general anesthesia and via the use of Gillies approach. The result of surgery was evaluated by postoperative facial computed tomography. RESULTS: Sixteen patients underwent surgery for zygomatic arch fracture. The patients had the average age of 41.3 years, a male predominance of 15:1 and physical assault as the most common cause of trauma. The time lag between injury and surgical reduction was 5.5 days. The surgical outcomes were assessed “good” in 14 cases and “moderate” in one case. Patients who had trismus preoperatively were resolved of it in all cases after operation. Postoperative complications were absent. CONCLUSION: The Gillies approach proved to be a relatively easy, safe, and reliable method, and its surgical outcomes was satisfactory in our experiences.

MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts

Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. The expression levels of miR-221 in the different groups were measured by qRT-PCR. Then, miR-221 mimic and inhibitor were transfected into MC3T3-E1 cells, and cell viability and migration were measured using the CCK-8 assay and the Transwell migration assay. Additionally, the expression levels of differentiation-related factors (Runx2 and Ocn) and ZFPM2 were measured by qRT-PCR. Western blot was used to measure the expression of cell cycle-related proteins, epithelial-mesenchymal transition (EMT)-related proteins, ZFPM2, and Wnt/Notch, and Smad signaling pathway proteins. miR-221 was significantly up-regulated in the patients with lumbar compression fracture (LCM) and trochanteric fracture (TF). miR-221 promoted ALP, Runx2, and OPN expressions in MC3T3-E1 cells. miR-221 overexpression significantly increased cell proliferation, migration, differentiation, and matrix mineralization, whereas suppression of miR-221 reversed these effects. Additionally, the results displayed that ZFPM2 was a direct target gene of miR-221, and overexpression of ZFPM2 reversed the promoting effects of miR-221 overexpression on osteoblasts. Mechanistic study revealed that overexpression of miR-221 inactivated the Wnt/Notch and Smad signaling pathways by regulating ZFPM2 expression. We drew the conclusions that miR-221 overexpression promoted osteoblast proliferation, migration, and differentiation by regulation of ZFPM2 expression and deactivating the Wnt/Notch and Smad signaling pathways.

Research progress on the relationship between osteosarcopenic obesity syndrome and fracture / 中华老年医学杂志

The ageing process is accompanied by osteoporosis,sarcopenia and obesity,which are named as osteosarcopenic obesity(OSO)syndrome.It is a recently identified syndrome characterized by simultaneous presence of osteopenia/osteoporosis,sarcopenia and increased adiposity(obesity),with a potential interconnection within these diseases via common pathophysiology.OSO is harmful for the elderly's physical-mental health and living quality,especially for bone fracture.Therefore,we reviewed a research progress on the relationship between OSO and fractures in the elderly.

Advance in Facial Nerve Decompression for Facial Palsy Resulting from Zygomatic Fractures (review) / 中国康复理论与实践

@#The facial nerve is the longest nerve shaped the bone tube, which has many turnings and narrow path. About 7% to 10% of patients with temporal bone fracture have facial paralysis. Most of the patients showed loss of frontal lines, inability to close eyes, and deflection of the teeth. Facial nerve decompression has been an effective way to relieve the symptoms and restore facial nerve functions. However, the issue of surgical indications, timing of surgery, and scope of decompression still need further research.

Panfacial bone fracture: cephalic to caudal

Theoretically, panfacial bone fractures involve all three areas of the face: frontal bone, midface, and mandible. In practice, when two out of these three areas are involved, the term “panfacial bone fracture” has been applied. We can use physical examination, simple radiologic examination, and computed tomography study for diagnosis. Linear fracture are treated by conservative treatment. But, most of panfacial bone fracture patients need to be treated by open reduction and internal fixation. Facial width is most important thing that we need to care during operation. There are many ways about sequence like “top to bottom,”“bottom to top,”“outside to inside,” or “inside to outside” and the authors prefer “top to bottom” and “outside to inside” ways. The authors apply arch bar from the first of surgery and then, set frontal bone fracture, midface fracture and mandible fracture in sequence. Usually, we remove the stitches for 5 days after surgery and the intraoral stitch removed after 2 weeks. Usually arch bar is going to be removed 4 weeks after surgery. We could get acceptable results with the above way.

Fracturas orbitarias / Orbital fractures

Introducción: las fracturas de la órbita son comunes y difíciles de manejar. Objetivo: realizar una revisión bibliográfica sobre las consideraciones anatómicas, fisiopatología, diagnóstico, tratamiento y complicaciones de las fracturas orbitarias. Métodos: se realizó una revisión bibliográfica en septiembre de 2016. Se evaluaron revistas de impacto de Web of Sciencies (35 revistas). Se consultaron las bases de datos MEDLINE, PubMed y SciELO con los descriptores: orbital fracture, treatment, epidemiology. Se incluyeron artículos en idioma inglés y español de los últimos 5 años. Se obtuvieron 127 artículos. El estudio se circunscribió a 47. Análisis e integración de la información: la órbita presenta debilidad anatómica en el piso y la pared medial que provoca una mayor afectación por fracturas. Existen varias teorías que justifican su aparición. El diagnóstico se basa en los hallazgos clínicos, incluidos los oftalmológicos, y medios auxiliares de diagnóstico; lo cual permite escoger la modalidad terapéutica y evitar complicaciones. Conclusiones: basados en el dominio de la anatomía y los métodos diagnósticos, la gestión de estas lesiones ha cambiado poco en los últimos años. Sin embargo, los avances en las imágenes orbitales, la introducción de sistemas de navegación intraoperatoria, mejores indicaciones quirúrgicas y diseños de implantes han llevado a una reevaluación del enfoque terapéutico de las fracturas orbitarias(AU)

Introduction: fractures of the orbit are common and difficult to manage. Objective: to carry out a bibliographic review on anatomical considerations, physiopathology, diagnosis, treatment and complications of orbital fractures. Methods: abibliographic review was carried out in September 2016. Journals of impact in the Web of Sciences (35 journals) were evaluated. The databases MedLine, PubMed and ScieELO were consulted with the descriptors: orbital fracture, treatment, and epidemiology. Articles in English and Spanish language of the last 5 years were included. 127 articles were obtained. The study was circumscribed to 47. Analysis and integration of information: the orbit presents anatomical weakness in the floor and the medial wall, which causes greater affectation due to fractures. There are several theories that justify its onset. The diagnosis is based on clinical findings, including ophthalmological findings, and diagnostic aids, which allows choosing the therapeutic modality and avoiding complications. Conclusions: based on the mastery of anatomic and diagnostic methods, the management of these lesions has changed little in recent years. However, advances in orbital imaging, the introduction of intraoperative navigation systems, better surgical indications and implant designs have led to a reassessment of the therapeutic approach to orbital fractures(AU)

Características clínicas e padrão de fraturas no momento do diagnóstico de osteogênese imperfeita em crianças / Clinical features and pattern of fractures at the time of diagnosis of osteogenesis imperfecta in children

RESUMO Objetivo: Caracterizar o padrão de fraturas e a história clínica no momento do diagnóstico de osteogênese imperfeita. Métodos: Neste estudo retrospectivo, foram incluídos todos os pacientes com osteogênese imperfeita de ambos os sexos, com idades entre 0 e 18 anos, que realizaram tratamento entre 2002 e 2014. Os prontuários médicos foram revisados para coleta de dados clínicos, incluindo presença de escleras azuladas, dentinogênese imperfeita, história familiar positiva para a doença e locais das fraturas, além de achados radiográficos no momento do diagnóstico. Resultados: Foram incluídos no estudo 76 pacientes (42 do sexo feminino), com idade, no momento do diagnóstico, entre 0 e 114 meses [mediana (p25-p75) de idade de 38 (6-96) meses]. Escleras azuladas estavam presentes em 93,4% dos pacientes, dentinogênese imperfeita foi observada em 27,6% e ossos wormianos em 29,4%. O número de fraturas ao diagnóstico variou entre 0 e 17, com uma mediana de 3 (2-8) fraturas. Em 40 (57%) pacientes, as fraturas eram de membros superiores e inferiores no momento do diagnóstico e, em 9 pacientes também havia fratura vertebral. O diagnóstico foi realizado ao nascimento em 85,7% dos pacientes com o tipo 3 e em 39,3% daqueles com tipo 4/5 da doença. Conclusões: Osteogênese imperfeita é uma doença genética com características clínicas distintas, tais como fragilidade óssea, fraturas recorrentes, escleras azuladas e dentinogênese imperfeita. É importante saber identificar essas características, facilitando o diagnóstico, otimizando o tratamento e diferenciando de outras doenças que também podem causar fraturas.

ABSTRACT Objective: To characterize the fracture pattern and the clinical history at the time of diagnosis of osteogenesis imperfecta. Methods: In this retrospective study, all patients with osteogenesis imperfecta, of both genders, aged 0-18 years, who were treated between 2002 and 2014 were included. Medical records were assessed to collect clinical data, including the presence of blue sclerae, dentinogenesis imperfecta, positive familial history of osteogenesis imperfecta, and the site of the fractures. In addition, radiographic findings at the time of the diagnosis were reviewed. Results: Seventy-six patients (42 females) were included in the study. Individuals' age ranged from 0 to 114 months, with a median (interquartile range) age of 38 (6-96) months. Blue sclerae were present in 93.4% of patients, dentinogenesis imperfecta was observed in 27.6% of patients, and wormian bones in 29.4% of them. The number of fractures at diagnosis ranged from 0 to 17, with a median of 3 (2-8) fractures. Forty (57%) patients had fractures of the upper and lower extremities, and 9 patients also had spinal fractures. The diagnosis was performed at birth in 85.7% of patients with type 3, and 39.3% of those with type 4/5 of the disorder. Conclusions: Osteogenesis imperfecta is a genetic disorder with distinctive clinical features such as bone fragility, recurrent fractures, blue sclerae, and dentinogenesis imperfecta. It is important to know how to identify these characteristics in order to facilitate the diagnosis, optimize the treatment, and differentiate osteogenesis imperfecta from other disorders that also can lead to fractures.

Clinical Significance of Serum Biomarker S100B to Predict Outcome After Traumatic Brain Injury in Adults

Background Traumatic brain injury (TBI) is a common cause of death and disability, worldwide. Early recognition of patients with brain cellular damage allows for early rehabilitation and patient outcome improvement. Serum protein S-100B determinations have been widely suggested the most promising biomarker for TBI. It has been proposed that this marker is useful in a Neurointensive Care Unit (NICU) as a monitoring parameter. The main objective of this study is to assess the value of including acute S100B levels in standard clinical data as an early screening tool for brain death after severe TBI. Material and methods In this prospective study, the clinical conditions of patients with mild to moderate TBI were assessed and patient serum S100B levels measured within 24h of injury were eligible for inclusion in the study using by electro chemi luminescence (ECL). Patients were admitted to The Govt. Trauma Centre, P.B.M. Hospital, Bikaner in NICU and followed up one month later and evaluated for level of consciousness, presence or absence of post-traumatic headache, and daily activity performance (using the Barthel scale). Student's t-test and the chi-square test were used for the data analysis, which was performed using SPSS software. Result and discussion The mean serum S100B value was significantly lower for patients with minor TBI than for patients with moderate TBI (20.4 ± 12.6 ng/dl and 124.0 ± 235.0 ng/dl, respectively). Patients with normal CT scans also had statistically significantly lower serum S100B levels than patients with abnormal CT findings. The mean S100B value was statistically significantly higher for patients with suspected diffused axonal injury (596.18 ± 502.1 ng/dl) than for patients with other abnormal CT findings (p=0.000): 20.97 ± 19.9 ng/dl in patients with normal CT results; 39.56 ± 21.7 ng/dl in patients with skull bone fracture; 50.38 ± 22.9 ng/dl in patients with intracranial haemorrhage; and 70.23 ± 31.3 ng/dl in patients with fracture plus intracranial haemorrhage. Conclusion Serum S100B levels increase in patients with minor to moderate TBIs, especially in those with diffused axonal injury. However, serum S100B values cannot accurately predict one-month neuropsychological outcomes and performance.